GnRH Agonists-Definition, Effects,The Good, Risks and side Effects

I. Definition
GnRH is a hormone released by the hypothalamus which stimulates the pituitary to produce luteinising hormones (LH) and follicle that stimulate hormone (FSH) to drive a menstrual cycle.

II. Effectiveness of GnRH
Just likes progesterone-like agonists, GnRH ( gonadotrophin-releasing hormone) have been used in treating endometriosis, for more than 20 years. They come in different forms: three-monthly injection, monthly injection, daily injection and nasal spray because of their chemical make up. GnRH are natural hormone blocking medicines, they help to stop the ovulation and create a temporary menopause state.
Study shows that GnRH are effective in reducing the symptoms and the size of endometrial implants but unfortunately, symptoms tend to return after stopping treatment in 4 months.


III. The Good
1) It helps to induce a menopause state, thereby reducing symptoms of menstrual cramps.
2.) It also uses to treat heavy menstruation, if other drugs failed.
3) Ovulation usually comes back within a month of stopping the drugs.
4) Reduce symptoms and sizes of endometrial implants because the drug creates the menopause state and stop the ovulation.
5) It can be given as an injection one a month or nostril spray.
6) Endometrial implants may be returned back to it original size within a few months after stop taking the medicine.

III. Risks
1. Loss of bone density
Loss of bone density is normal for women taking the GnRH drug. Since it causes menopause state, it deplete the calcium in the body that is essential for building a healthy bone. It also distorts the ratio of magnesium and calcium.
2) Reducing sexual desire
Sexual libido may be caused by dry vagina, one of many symptoms of GnRH. It may also be caused by low level of estrogen that is essential for driving sexual desire.
3) Increase the risk of developing of ovarian cysts.

IV. Side effects
a) Hot flush, dry vagina caused by temporary of menopause state.
b) Loss of libido caused by low level of estrogen and vagina dryness.
c) Loss of bone density caused by low level of estrogen and progesterone.
d) Nutritional deficiency caused by symptoms of menopause state as our body is no longer absorb magnesium and calcium effectively.



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